MP43-05 S-NITROSOGLUTATHIONE REDUCTASE (GSNOR) DEFICIENCY IS A NOVEL MODEL OF SECONDARY HYPOGONADISM
نویسندگان
چکیده
منابع مشابه
S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells.
Although nitric oxide (NO) signaling promotes differentiation and maturation of endothelial progenitor cells, its role in the differentiation of mesenchymal stem cells (MSCs) into endothelial cells remains controversial. We tested the role of NO signaling in MSCs derived from WT mice and mice homozygous for a deletion of S-nitrosoglutathione reductase (GSNOR(-/-)), a denitrosylase that regulate...
متن کاملHuman carbonyl reductase 1 is an S-nitrosoglutathione reductase.
Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds including xenobiotics. In addition, hCBR1 possesses a glutathione binding site that allows for increased affinity toward GSH-conjugated molecul...
متن کاملS-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction.
AIMS Nitric oxide (NO) production is implicated in muscle contraction, growth and atrophy, and in the onset of neuropathy. However, many aspects of the mechanism of action of NO are not yet clarified, mainly regarding its role in muscle wasting. Notably, whether NO production-associated neuromuscular atrophy depends on tyrosine nitration or S-nitrosothiols (SNOs) formation is still a matter of ...
متن کاملLymphocyte development requires S-nitrosoglutathione reductase.
NO is critical to immunity, but its role in the development of the immune system is unknown. In this study, we show that S-nitrosoglutathione reductase (GSNOR), a protein key to the control of protein S-nitrosylation, is important for the development of lymphocytes. Genetic deletion of GSNOR in mice results in significant decrease in both T and B lymphocytes in the periphery. In thymus, GSNOR d...
متن کاملLocalization of S-nitrosoglutathione and expression of S-nitrosoglutathione reductase in pea plants under cadmium stress.
S-nitrosoglutathione (GSNO) is considered a natural nitric oxide (NO.) reservoir and a reactive nitrogen intermediate in animal cells, but little is known about this molecule and its metabolism in plant systems. In this work, using pea plants as a model system, the presence of GSNO in collenchyma cells was demonstrated by an immunohistochemical method. When pea plants were grown with a toxic Cd...
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ژورنال
عنوان ژورنال: Journal of Urology
سال: 2018
ISSN: 0022-5347,1527-3792
DOI: 10.1016/j.juro.2018.02.1404